Soluble CD93 lectin-like domain sequesters HMGB1 to ameliorate inflammatory diseases
نویسندگان
چکیده
منابع مشابه
Thrombomodulin's lectin-like domain reduces myocardial damage by interfering with HMGB1-mediated TLR2 signalling.
AIMS Thrombomodulin (TM), via its lectin-like domain (LLD), exhibits anti-inflammatory properties partly by sequestering the pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Since myocardial damage after ischaemia and reperfusion is mediated by inflammation, we evaluated the cardioprotective effects of the LLD of TM. Using an in vivo mouse model of transient ischaemia and in vitro ...
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ژورنال
عنوان ژورنال: Theranostics
سال: 2023
ISSN: ['1838-7640']
DOI: https://doi.org/10.7150/thno.84935